Portal de Periódicos da CAPES

Fluoride-induced lesions in the teeth of the short-tailed field vole (Microtus agrestis): A description of the dental pathology

1997; Wiley; Volume: 232; Issue: 2 Linguagem: Inglês

10.1002/(sici)1097-4687(199705)232

1097-4687

I.C. Boulton, J. A. Cooke, Matthew Johnson,

Wildlife Ecology and Conservation

Journal of MorphologyVolume 232, Issue 2 p. 155-167 Fluoride-induced lesions in the teeth of the short-tailed field vole (Microtus agrestis): A description of the dental pathology I.C. Boulton, Corresponding Author I.C. Boulton School of Environmental Sciences, University of Greenwich, London SE8 3BW, United KingdomSchool of Environmental Sciences, University of Greenwich, Creek Road, Deptford, London SE8 3BW, UKSearch for more papers by this authorJ.A. Cooke, J.A. Cooke Department of Biology, University of Natal, Durban 4001, South AfricaSearch for more papers by this authorM.S. Johnson, M.S. Johnson Industrial Ecology Research Centre, Department of Environmental and Evolutionary Biology, University of Liverpool, Liverpool L69 3BX, United KingdomSearch for more papers by this author I.C. Boulton, Corresponding Author I.C. Boulton School of Environmental Sciences, University of Greenwich, London SE8 3BW, United KingdomSchool of Environmental Sciences, University of Greenwich, Creek Road, Deptford, London SE8 3BW, UKSearch for more papers by this authorJ.A. Cooke, J.A. Cooke Department of Biology, University of Natal, Durban 4001, South AfricaSearch for more papers by this authorM.S. Johnson, M.S. Johnson Industrial Ecology Research Centre, Department of Environmental and Evolutionary Biology, University of Liverpool, Liverpool L69 3BX, United KingdomSearch for more papers by this author First published: 06 January 1999 https://doi.org/10.1002/(SICI)1097-4687(199705)232:2 3.0.CO;2-9Citations: 8AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract The effect of fluoride on the appearance of the teeth of the short-tailed field vole. Microtus agrestis, was investigated in both wild animals collected from field sites affected by different levels of industrial fluoride contamination and laboratory-reared animals consuming experimental grass diets of known fluoride concentration or with known fluoride concentrations in drinking water. The extent and severity of lesions on the surface and structure of both incisors and molars are described as six lesion types and related to the amount of biologically available orally ingested fluoride. In the incisors of voles consuming relatively low fluoride diets, lesions are mainly confined to those resulting from disruption of enamel pigmentation expressing itself as concentric bands of pigmentation-free areas on incisor surfaces. The visible effects on molars at low fluoride levels are confined to minor alterations in surface appearance. At higher levels of available dietary fluoride, effects on enamel pigmentation are superseded by alterations in the formation, composition, and strength of both enamel and dentine. The incisors exhibit a marked to severe increase in the cutting tip erosion rates with comparable increases in the extent of abnormal surface changes (enamel hypoplasia) and loss of enamel pigmentation. The grinding surfaces of molars from animals exposed to high levels of dietary fluoride exhibit increasingly severe erosion of outer enamel regions, combined with cavitation and staining of the exposed central dentine. The mechanisms through which fluoride elicits increasingly visible and pathological alterations to the surface and subsurfaces of rodent teeth are discussed. J Morphol 232: 155–167, 1997. © 1997 Wiley-Liss, Inc. Literature Cited Abe, T., M. Masuoka, M. Nomura, and H. Miyajima (1986) Effects of fluoride on developing enamel and dentin of rat incisors. In H. Tsunoda, and M.-H. Yu (eds): Fluoride Research 1985, Studies in Environmental Science Number 27, Amsterdam: Elsevier, pp. 299–305. 10.1016/S0166-1116(08)71855-7 Web of Science®Google Scholar Andrews, S. M., J. A. Cooke and M. S. Johnson (1989) Distribution of trace element pollutants in a contaminated ecosystem established on metalliferous fluorspar tailings, 3: Fluoride. Environ. Pollut. 60: 165–179. 10.1016/0269-7491(89)90225-X CASPubMedWeb of Science®Google Scholar Baker, J. B., and J. R. Clarke (1987) Voles. In Poole (ed): UFAW Handbook on the Cara and Management of Laboratory Animals. 6th ed. Essex: Longman, pp. 331–345. Google Scholar Bouliere, F., (1975) mammals, small and large: the ecological implications of size. In F. Golley, K. Petrusewicz, and L. Ryszkowski (eds): Small Mammals: Their Productivity and Population Dynamics. Cambridge: Cambridge University Press, pp. 1–8. Google Scholar Boulton, I. C., J. A. Cooke, and M. S. Johnson (1994a) Fluoride accumlation and toxicity in wild small mammals. Environ. Pollut. 85: 161–167. 10.1016/0269-7491(94)90082-5 CASPubMedWeb of Science®Google Scholar Boulton, I. C., J. A. Cooke, and M. S. Johnson (1994b) Experimental fluoride accumlulation and toxicity in the short-tailed field vole (Microtus agrestis.). J. Zool. Lond. 234: 409–421. 10.1111/j.1469-7998.1994.tb04856.x Web of Science®Google Scholar Boulton, I. C., J. A. Cooke, and M. S. Johnson (1994c) Age-accumulation of fluoride in an experimental population of shorttailed field voles (Microtus agrestis L.). Sci. Total Environ. 94: 29–37. 10.1016/0048-9697(94)90611-4 Web of Science®Google Scholar Boulton, I. C., J. A. Cooke, and M. S. Johnson (1995) Experimental comparison of fluoride accumulation and toxicity in three species of wild small mammal and the laboratory mouse. J. Appl. Toxicol. 15: 423–431. 10.1002/jat.2550150602 CASPubMedWeb of Science®Google Scholar Carleton, M. D. (1985) Macroanatomy. IN R. H. Tamarin (ed): Biology of New World Microtus. Provo. UT: Special Publication, American society of Mammalogists No. 8. pp. 116–175. Google Scholar Cooke, J. A., I. C. Boulton, and M. S. Johnson (1996) Fluoride in small mammals. In W. N. Beyer, G. H. Heinz, and A. W. Redmon-Norwood (eds): Environmental Contaminants in Wildlife: Interpreting Tissue concetrations. SETAC Special Publication Series. Boca raton, FL: CRC Press, pp. 473–482. Web of Science®Google Scholar Corbet, G. B., and S. Harris (1991) Handbook of British mammals, 3rd ed. Oxford: Blackwell. Google Scholar Corbet, G. B., and D. Ovenden (1980) The mammals of Britain and Europe, London: Collins. Google Scholar De Lopez, O. H., F. A. Smith, and H. C. Hodge (1976) Plasma fluoride concentrations inrats acutely poisoned with sodium fluoride. Toxicol. Appl. Pharmacol. 37: 75–83. 10.1016/S0041-008X(76)80009-9 CASPubMedWeb of Science®Google Scholar Fejerskov, O., A. Richards, and K. Josephsen (1983) Pathogenesis and biochemical findings of dental fluorosis in various species. In J. L. Shupe H. B. Peterson, and N. C. Leone (eds): Fluorides: Effects on Vegetation, Animals and Humans. Salt Lake City. UT: Paragon Press. pp. 305–317. Google Scholar Flowerdew, J. (1993) Mice and Voles. London: Whittet Books. Google Scholar McBee, K., and J. W. Bickham (1990) Mammals as bioindicators of environmental toxicity. In H. H. Genoways (ed): Current Mammalogy. Vol. 2, New York and London: Plenum Press. pp. 37–87. Google Scholar Milhaud, G. E., M. A. Borba, and S. Krishnaswarmy (1987) Effect of fluoride ingestion on dental fluorosis in sheep. Am. J. Vet. Res. 48: 873–879. CASPubMedWeb of Science®Google Scholar National Academy of Sciences (NSA) (1974) Effects of Fluorides in Animals. Washington, DC: National Academy of Sciences. Google Scholar Nordlund, A. L., J. L. Ekstrand, and L. Hammarstrom (1986) Fluoride-induced cystic changes in the enamel organ of the rat. J. Oral Pathol. 15: 87–92. 10.1111/j.1600-0714.1986.tb00583.x CASPubMedWeb of Science®Google Scholar Oxberry, B. A. (1975) An anatomical, histochemical and autoradiographic study of the ever-growing molar dentition of Microtus with comments on the role of structure in growth and eruption. J. Morphol. 147: 337–354. 10.1002/jmor.1051470307 CASPubMedWeb of Science®Google Scholar Shupe, J. L., and A. E. Olson (1983) Clinical and pathological aspects of fluoride toxicosis in animals. In J. L. Shupe, H. B. Peterson, and N. C. Leone (eds): Fluorides: Effects on Vegetation, Animals and Humans. Salt Lake City, UT Paragon Press Inc., pp. 319–338. Google Scholar Shupe, J. L., A. E. Olson, H. B. Peterson, and J. B. Low (1984) Fluoride toxicosis in wild ungulates. J. Am. Vet. Med. Assoc. 185: 1295–1300. CASPubMedWeb of Science®Google Scholar Shupe, J. L., P. V. Christofferson, A. E. Olson, E. S. Allred, and R. L. Hurst (1987) Relationship of cheek tooth abrasion to fluoride-induced permanent incisor lesions in livestock. Am. J. Vet. Res. 48: 1498–1503. CASPubMedWeb of Science®Google Scholar Simmelink, J. W., and A. Lange (1986) Ultrastructure of altered rat enamel beneath fluoride-induced cysts. J. Oral Pathol. 15: 155–161. 10.1111/j.1600-0714.1986.tb00598.x CASPubMedWeb of Science®Google Scholar Talmage, S. S., and B. T. Walton (1991) Small mammals as monitors of environmental contaminants. Rev. Environ. Contam. Toxicol. 119: 47–145. 10.1007/978-1-4612-3078-6_2 CASPubMedWeb of Science®Google Scholar Walton, K. C. (1987a) Extraction of fluoride from soil with water, and with hydrochloric acid simulating predator gastric juices. Sci. Total Environ. 65: 247–256. 10.1016/0048-9697(87)90177-X CASWeb of Science®Google Scholar Walton, K. C. (1987b) Tooth damage field voles. wood mice and moles in areas polluted by fluoride from an aluminium reduction plant. Sci. Total Environ. 65: 257–260. 10.1016/0048-9697(87)90178-1 CASPubMedWeb of Science®Google Scholar Walton, R. E., and D. R. Eisenmann (1974) Ultrastructural examinationof various stages of amelogenesis in the rat following parenteral fluoride administration. Arch. Oral Biol. 19: 171–182. 10.1016/0003-9969(74)90212-X CASPubMedWeb of Science®Google Scholar Weatherell, J. A., D. Deutsch, C. Robinson, and A. S. Hallsworth (1977) Assimilation of fluoride by enamel throughout the life of the tooth. Caries Res. 11(Suppl. 1) 85–115. 10.1159/000260297 PubMedGoogle Scholar Whitford, G. M., (1989) The Metabolism and Toxicity of Fluoride. Monographs in Oral Science. Vol. 13, Basel: H. H. Karger. Google Scholar World Health Organization (WHO) (1984) Fluorine and Fluorides. Environmental Health Criteria 36. Geneva: World Health Organization. Google Scholar Wright, D. A., A. W. Davison, and M. S. Johnson (1978) Fluoride accumlation by long-tailed field mice(Apodemus sylvaticus L.) and field voles (Microtus agrestis L.) from polluted environements Environ. Pollut. 17: 303–317. 10.1016/0013-9327(78)90095-2 CASWeb of Science®Google Scholar Citing Literature Volume232, Issue2May 1997Pages 155-167 ReferencesRelatedInformation