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In situ identification of hepatitis C virus RNA in muscle

2005; Lippincott Williams & Wilkins; Volume: 64; Issue: 6 Linguagem: Inglês

10.1212/01.wnl.0000154605.02737.fe

1526-632X

Hisao Ito, Hisao Ito, Mamoru Nagano, Satoshi Nakano, Yasufumi Shigeyoshi, Hirofumi Kusaka,

HIV-related health complications and treatments

The authors examined skeletal muscle specimens from four patients with myositis and hepatitis C virus (HCV) infection. PCR analysis identified HCV RNA in muscle homogenates from two patients. In situ hybridization signals for HCV RNA were detected within muscle fibers as well as in infiltrating lymphocytes from the same patients. The results may relate to the pathomechanism of myositis in patients with HCV infection.