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An overview of the fission yeast septation initiation network (SIN)

2008; Portland Press; Volume: 36; Issue: 3 Linguagem: Inglês

10.1042/bst0360411

1470-8752

Andrea Krapp, Viesturs Simanis,

Genetic Neurodegenerative Diseases

The fission yeast septation initiation network, or SIN, is a signal transduction network that is required for septum formation in Schizosaccharomyces pombe. Its activity is tightly regulated through the cell cycle, to ensure proper co-ordination of mitosis and cytokinesis. SIN signalling requires three protein kinases for its function and is mediated by a ras-superfamily GTPase. We discuss the elements of the SIN and how they are regulated.