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IMMUNOLOGICAL CROSS‐REACTION BETWEEN ANTIGEN Tp‐4 OF TREPONEMA PALLIDUM AND AN ANTIGEN COMMON TO A WIDE RANGE OF BACTERIA

1984; Wiley; Volume: 92B; Issue: 1-6 Linguagem: Inglês

10.1111/j.1699-0463.1984.tb02818.x

0108-0180

Peter Hindersson, C S Petersen, Nils Strandberg Pedersen, Niels Høiby, N. H. AXELSEN,

Immune responses and vaccinations

By electro‐immunoprecipitation methods it was shown that antigen Tp—4 of Treponema pallidum , antigen TR‐c of the Reiter treponeme and ‘Common Antigen’ of Pseudomonas aeruginosa are immunologically cross‐reactive. This finding establishes a taxonomic relationship between T. pallidum and a wide range of bacteria. The cross‐reactivity explains some false positive reactions in serodiagnostic treponemal tests for syphilis. The cross‐reactivity may also play a role in a possible ‘normal’ immunity against infection with T. pallidum induced by antigens by the normal human bacterial flora.