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Brain natriuretic peptide and left ventricular dysfunction in Chagas' disease

2002; Elsevier BV; Volume: 360; Issue: 9331 Linguagem: Inglês

10.1016/s0140-6736(02)09638-1

1474-547X

Antônio Luiz Pinho Ribeiro, Adelina M. Reis, Márcio Vinícius Lins Barros, Marcos Roberto de Sousa, Ana Luiza Lunardi Rocha, Amanda Arantes Perez, Jacqueline Braga Pereira, Fernando Santana Machado, Manoel Otávio da Costa Rocha,

Cardiovascular Function and Risk Factors

Left ventricular dysfunction in Chagas' disease is common but can be difficult to detect. We investigated whether measurement of plasma brain natriuretic peptide (BNP) could identify patients with left ventricular dysfunction who need further investigation or treatment. Among patients with an abnormal electrocardiogram or chest radiograph, a BNP concentration of 60·7 pmol/L or higher has a sensitivity and positive predictive value of 80%, and specificity and negative predictive value of 97%. Measurement of plasma BNP concentration could be a useful method to screen patients with Chagas' disease.