Stability of meropenem and effect of 1 beta-methyl substitution on its stability in the presence of renal dehydropeptidase I
1992; American Society for Microbiology; Volume: 36; Issue: 7 Linguagem: Inglês
10.1128/aac.36.7.1577
ISSN1098-6596
AutoresMASATOMO FUKASAWA, Yoshihiro Sumita, E.T. Harabe, Tomoharu Tanio, HIROSHI NOUDA, Tsuneo Kohzuki, T. OKUDA, Hideaki Matsumura, Masataka Sunagawa,
Tópico(s)Antibiotic Resistance in Bacteria
ResumoThe stability of meropenem in the presence of renal dehydropeptidase I (DHP-I) varied extremely with the animal source of the enzyme. Meropenem, compared with imipenem, was rather easily hydrolyzed by DHP-Is from mice, rabbits, and monkeys, while it showed a higher resistance to guinea pig and beagle dog DHP-Is. In addition, meropenem was four times more resistant than imipenem to human DHP-I. The 1 beta-methyl substituent on carbapenems, i.e., meropenem and 1 beta-methyl imipenem, made them considerably more resistant to mouse and swine DHP-Is than the 1-unsubstituted derivatives are.
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