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Unraveling the Sense of Smell (Nobel Lecture)

2005; Wiley; Volume: 44; Issue: 38 Linguagem: Inglês

10.1002/anie.200501120

1521-3773

Linda B. Buck,

Neurobiology and Insect Physiology Research

Angewandte Chemie International EditionVolume 44, Issue 38 p. 6128-6140 Review Unraveling the Sense of Smell (Nobel Lecture)† Linda B. Buck Dr., Linda B. Buck Dr. [email protected] Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109-1024, USA, Fax: (+1) 206-667-1031Search for more papers by this author Linda B. Buck Dr., Linda B. Buck Dr. [email protected] Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109-1024, USA, Fax: (+1) 206-667-1031Search for more papers by this author First published: 20 September 2005 https://doi.org/10.1002/anie.200501120Citations: 171 † Copyright© The Nobel Foundation 2004. We thank the Nobel Foundation, Stockholm, for permission to print this lecture. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract A sense of occasion: Around 20 years after the start of their pioneering studies on the function of the nose and brain in odor perception, R. Axel and L. Buck have received the 2004 Nobel Prize for Medicine or Physiology. The picture shows schematically the coding of different odors in the olfactory epithelium (OE) and olfactory bulb (OB). References 1“Chemical transmission in the nose of the frog”: R. C. Gesteland, J. Y. Lettvin, W. H. 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Neurosci. 1999, 22, 487–509. 9“The complete human olfactory subgenome”: G. Glusman, I. Yanai, I. Rubin, D. Lancet, Genome Res. 2001, 11, 685–702. 10“The human olfactory receptor repertoire”: S. Zozulya, F. Echeverri, T. Nguyen, Adv. Genome Biol. 2001, 2, RESEARCH 0018. 11“Different evolutionary processes shaped the mouse and human olfactory receptor gene families”: J. M. Young, C. Friedman, E. M. Williams, J. A. Ross, L. Priddy-Tonnes, B. J. Trask, Hum. Mol. Genet. 2002, 11, 535–546. 12“The olfactory receptor gene superfamily of the mouse”: X. Zhang, S. Firestein, Nat. Neurosci. 2002, 5, 124–133. 13“The mouse olfactory receptor gene family”: P. A., Godfrey, B. Malnic, L. B. Buck, Proc. Natl. Acad. Sci. USA 2004, 101, 2156–2161. 14“The human olfactory receptor gene family”: B. Malnic, P. A. Godfrey, L. B. Buck, Proc. Natl. Acad. Sci. USA 2004, 101, 2584–2589. 15a“A novel family of genes encoding putative pheromone receptors in mammals”: C. Dulac, R. Axel, Cell 1995, 83, 195–206; 15b“A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution”: G. Herrada, C. Dulac, Cell 1997, 90, 763–773. 16“A multigene family encoding a diverse array of putative pheromone receptors in mammals”: H. Matsunami, L. B. Buck, Cell 1997, 90, 775–784. 17“A new multigene family of putative pheromone receptors”: N. J. Ryba, R. Tirindelli, Neuron 1997, 19, 371–379. 18“A zonal organization of odorant receptor gene expression in the olfactory epithelium”: K. J. Ressler, S. L. Sullivan, L. B. Buck, Cell 1993, 73, 597–609. 19“Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium”: R. Vassar, J. Ngai, R. Axel, Cell 1993, 74, 309–318. 20“Combinatorial receptor codes for odors”: B. Malnic, J. Hirono, T. Sato, L. B. Buck, Cell 1999, 96, 713–723. 21“Functional expression of a mammalian odorant receptor”: H. Zhao, L. Ivic, J. M. Otaki, M. Hashimoto, K. Mikoshiba, S. Firestein, Science 1998, 279, 237–242. 22“Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb”: K. J. Ressler, S. L. Sullivan, L. B. Buck, Cell 1994, 79, 1245–1255. 23“Topographic organization of sensory projections to the olfactory bulb”: R. Vassar, S. K. Chao, R. Sitcheran, J. M. Nunez, L. B. Vosshall, R. Axel, Cell 1994, 79, 981–991. 24“Sensory discrimination with some recent evidence from the olfactory organ”: E. D. Adrian, Br. Med. Bull. 1950, 6, 330–333. 25“The action of the mammalian olfactory organ”: L. Adrian, J. Laryngol. Otol. 1956, 70, 1–14. 26“Information coding in the vertebrate olfactory system”: L. B. Buck, Annu. Rev. Neurosci. 1996, 19, 517–544. 27“The olfactory cortex”: L. B. Haberly in The synaptic organization of the brain (Ed.: ), Oxford University Press, New York, 1998, pp. 377–41. 28“A genetic approach to trace neural circuits”: L. F. Horowitz, J. P. Montmayeur, Y. Echelard, L. B. Buck, Proc. Natl. Acad. Sci. USA 1999, 96, 3194–3199. 29“Genetic tracing reveals a stereotyped sensory map in the olfactory cortex”: Z. Zou, L. F. Horowitz, J. P. Montmayeur, S. Snapper, L. B. Buck, Nature 2001, 414, 173–179. 30“The chromosomal distribution of mouse odorant receptor genes”: S. L., Sullivan, M. A. Adamson, K. J. Ressler, C. A. Kozak, L. B. Buck, Proc. Natl. Acad. Sci. USA 1996, 93, 884–888. Citing Literature Volume44, Issue38September 26, 2005Pages 6128-6140 This article also appears in:Nobel Lectures ReferencesRelatedInformation