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The Antinociceptive and Anti-Inflammatory Activities of Aspidosperma tomentosum (Apocynaceae)

2013; Hindawi Publishing Corporation; Volume: 2013; Issue: 1 Linguagem: Inglês

10.1155/2013/218627

2356-6140

Anansa Bezerra de Aquino, Luiz Henrique Agra Cavalcante‐Silva, Carolina Barbosa Brito da Matta, Willians Antônio do Nascimento Epifânio, Pedro Gregório Vieira Aquino, Antônio Euzébio Goulart Santana, Magna Suzana Alexandre‐Moreira, João Xavier de Araújo‐Júnior,

Phytochemistry and Bioactive Compounds

We investigated the antinociceptive and anti‐inflammatory activities of the crude ethanolic extract (CEE), its fractions, and the flavonoid isorhamnetin from Aspidosperma tomentosum using models of nociception and inflammation in mice. In the writhing test, the CEE and its fractions (except for soluble phase, CHCl 3 100% and EtAcO 100%) at 100 mg/kg p.o. induced antinociceptive activity. Isorhamnetin (100 μ mol/kg, p.o.) was also active. In the hot plate test, only the treatment with the fractions Hex : CHCl 3 50%, CHCl 3 100%, and CHCl 3 : MeOH 5% (100 mg/kg, p.o.) increased the latency time, reversed by the opioid antagonist naloxone. Fractions that were active in the hot plate test did not show catalepsy condition. It was observed that CEE, all fractions, and isorhamnetin reduced the formalin effects in the neurogenic phase. In the inflammatory phase, only CEE, isorhamnetin, and CHCl 3 100% and CHCl 3 : MeOH 5% fractions were active. CEE and all fractions, except for CHCl 3 : MeOH 10% fraction, isorhamnetin, and soluble fraction were able to produce an antioedematogenic activity in the ear capsaicin‐induced edema test. In the thioglycolate‐induced peritonitis, only EtAcO 100% fraction was not active. The results demonstrate that A. tomentosum has antinociceptive and anti‐inflammatory activities in animal models.