Voltar
Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Hepatoprotective Effect of the Aqueous Extract of Simarouba amara Aublet (Simaroubaceae) Stem Bark against Carbon Tetrachloride (CCl4)-Induced Hepatic Damage in Rats

2014; Multidisciplinary Digital Publishing Institute; Volume: 19; Issue: 11 Linguagem: Inglês

10.3390/molecules191117735

ISSN

1433-1373

Autores

H.M.L. Maranhão, Carlos Alberto Vasconcelos, Larissa Araújo Rolim, Pedró José Rolim Neto, Jacinto da Costa Silva Neto, Reginaldo Silva‐Filho, Mariana Pinheiro Fernandes, João Henrique Costa‐Silva, Alice Valença Araújo, Almir Gonçalves Wanderley,

Tópico(s)

Plant Toxicity and Pharmacological Properties

Resumo

Simarouba amara stem bark decoction has been traditionally used in Brazil to treat malaria, inflammation, fever, abdominal pain, diarrhea, wounds and as a tonic. In this study, we investigate the hepatoprotective effects of the aqueous extract of S. amara stem bark (SAAE) on CCl4-induced hepatic damage in rats. SAAE was evaluated by high performance liquid chromatography. The animals were divided into six groups (n = 6/group). Groups I (vehicle—corn oil), II (control-CCl4), III, IV, V and VI were pretreated during 10 consecutive days, once a day p.o, with Legalon® 50 mg/kg b.w, SAAE at doses 100, 250 and 500 mg/kg b.w, respectively. The hepatotoxicity was induced on 11th day with 2 mL/kg of 20% CCl4 solution. 24 h after injury, the blood samples were collected and their livers were removed to biochemical and immunohistochemical analyzes. The SAAE decreased the levels of liver markers and lipid peroxidation in all doses and increased the catalase levels at doses 250 and 500 mg/kg. Immunohistochemical results suggested hepatocyte proliferation in all doses. These results may be related to catechins present in SAAE. Thus, SAAE prevented the oxidative damage at the same time that increased regenerative and reparative capacities of the liver.

Referência(s)