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Transferrin receptor (CD71) expression on circulating mononuclear cells during pregnancy

1994; Elsevier BV; Volume: 170; Issue: 1 Linguagem: Inglês

10.1016/s0002-9378(94)70408-2

1097-6868

Diana W. Bianchi, Melissa C. Yih, Gretchen K. Zickwolf, Alan F. Flint,

Pregnancy and preeclampsia studies

Abstract OBJECTIVE: We studied transferrin receptor (CD71) expression in peripheral blood mononuclear cells from healthy pregnant women, to determine if a relationship existed between gestational age and circulating CD71 + mononuclear cells. STUDY DESIGN: Cell suspensions were prepared from venous blood from 139 pregnant women (7 to 26 weeks of gestation), incubated with monoclonal anti-CD71 antibody, and analyzed by flow cytometry. RESULTS: When only the first sample from each woman was analyzed, extensive biologic variation between women was shown. An apparent biphasic increase in the percentage of CD71 + cells with advancing gestation was suggested. A subgroup of 13 women studied on multiple occasions demonstrated linear increases in CD71 + cells as pregnancy progressed. CONCLUSIONS: Pregnant women, when compared with each other, may have differences in the baseline number of circulating CD71 + cells. The increases seen in individuals studied repeatedly are likely to reflect maternal hematopoiesis and current fetomaternal transfusion. (AM J OBSTET GYNECOL 1994;170:202-6.)