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Immunological characterization of subpopulations of mononuclear cells in tissue and peripheral blood from patients with sarcoidosis

1976; Academic Press; Volume: 5; Issue: 1 Linguagem: Inglês

10.1016/0090-1229(76)90156-2

1090-2341

H Tannenbaum, Geraldine S. Pinkus, Peter H. Schur,

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

The immunological characteristics of the mononuclear cells comprising sarcoid granulomas were studied in cryostat sections of eight lymph nodes and one lung biopsy. In eight of the nine tissues, the histiocytes in the center of the sarcoid granuloma had surface receptors for 7S γ-globulin. Surrounding these histiocytes was a mantle of B lymphocytes as identified by their complement receptors. The percentage of B and T lymphocytes in the circulation was normal in 24 patients with sarcoidosis, but a diminution in the absolute number of B and T cells was present due to the relative lymphopenia observed in the sarcoidosis subjects compared with the control group. It is postulated that the anatomic distribution of the various immunocompetent cells within the sarcoid granuloma may play an important role in the pathogenesis of sarcoidosis.