Homologous and heterologous passive cutaneous anaphylactic activity of mouse antisera during the course of immunization
1969; Elsevier BV; Volume: 8; Issue: 16 Linguagem: Inglês
10.1016/0024-3205(69)90099-x
ISSN1879-0631
Autores Tópico(s)Allergic Rhinitis and Sensitization
ResumoThe ability of mouse antisera collected at different times during the course of immunization to induce homologous and heterologous (rat) PCA using a sensitization period of 2 or 72 hours was studied. The following observations were made: a. The homologous PCA activity increased during immunization whereas the heterologous PCA activity decreased; b. The 72 hour PCA titer in mice was the same as the 2 hour PCA titer in rats; c. The 72 hour PCA activity in mice and the PCA activity in rats were both heat labile; d. Absorption of mouse antisera with rabbit anti-mouse 7Syl removed the 2 hour PCA activity in mice but not in rats. It is concluded that the 2 hour PCA activity of mouse antiserum in mice is due to 7Syl antibody whereas the 72 hour PCA activity in mice and the PCA activity in rats are due to a heat labile reagin like antibody. It is suggested that the PCA activity of mouse antisera in rats may be used as a specific measurement of mouse reagin-like antibody.
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