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On the value of menorrhagia as a predictor for coagulation disorders

1996; Wiley; Volume: 53; Issue: 4 Linguagem: Inglês

10.1002/(sici)1096-8652(199612)53

1096-8652

Måns Edlund, Margareta Blombäck, Bo von Schoultz, Ola Andersson,

Heparin-Induced Thrombocytopenia and Thrombosis

The value of menorrhagia as a predictor for mild bleeding disorders has been very little studied and the results are divergent. In the present study on 30 women with objectively verified menorrhagia, we found a significantly increased prevalence of von Willebrand's disease (20%). By keeping a strict sampling and laboratory routine, and by restricting sampling to cycle days 5-7, we also obtained a very low interindividual variation of von Willebrand factor and coagulation factor VIII. We conclude that menorrhagia is a valuable predictor for coagulation and platelet disorders, and that time of sampling is of importance. This should be considered in the investigation of menorrhagia, and can be a guideline in looking for mild bleeding disorders.