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Detection of Imported Malaria with the Cell-Dyn 4000 Hematology Analyzer

2002; American Society for Microbiology; Volume: 40; Issue: 12 Linguagem: Inglês

10.1128/jcm.40.12.4729-4731.2002

1098-660X

Peter C. Wever, Yvonne Henskens, Piet A. Kager, Jacob Dankert, Tom van Gool,

Complement system in diseases

ABSTRACT The sensitivity and specificity of the Cell-Dyn 4000 hematology analyzer in the diagnosis of imported malaria were studied with samples from patients in an academic hospital setting. The performance of the Cell-Dyn 4000 hematology analyzer was compared with that of conventional diagnostic methods for malaria. The Cell-Dyn 4000 hematology analyzer detected hemozoin-containing depolarizing monocytes in 29 of 58 patients with malaria and 2 of 55 patients without malaria. The presence or absence of depolarizing monocytes in patients with malaria was related to duration of symptoms before presentation for malaria analysis. A second parameter, pseudoreticulocytosis due to nuclear material of intraerythrocytic malaria parasites, was detected by the Cell-Dyn 4000 hematology analyzer almost exclusively in Plasmodium falciparum malaria patients with parasitemia levels of ≥0.5%. Attention to these abnormalities in medical centers without tropical disease expertise may decrease a delay in the diagnosis of malaria.