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Endotracheally Administered Gentamicin for the Prevention of Infections of the Respiratory Tract in Patients with Tracheostomy: A Double-Blind Study

1974; Elsevier BV; Volume: 65; Issue: 6 Linguagem: Inglês

10.1378/chest.65.6.650

1931-3543

Jean Klášterský, Eric Huysmans, Danièle Weerts, Colette Hensgens, D. Daneau,

Antibiotic Resistance in Bacteria

Endotracheal administration of gentamicin has been compared with saline injections in a double-blind study of 85 patients admitted to a neurosurgical unit with tracheostomy. Endotracheal administration of gentamicin reduced significantly the incidence of colonization of the tracheal secretions by Gram-negative rods (p<0.01) and decreased significantly the frequency of bacteriologically proved episodes of respiratory tract infections (p <0.01). Bacteria isolated from patients treated with gentamicin were slightly more resistant to gentamicin than the microorganisms recovered from the respiratory tract of salinetreated control patients. It is concluded that endotracheal administration of gentamicin to patients with tracheostomy may be a helpful adjunct to their management; however, special attention should be paid to the possible emergence of gentamicin-resistant microorganisms during this form of treatment. Endotracheal administration of gentamicin has been compared with saline injections in a double-blind study of 85 patients admitted to a neurosurgical unit with tracheostomy. Endotracheal administration of gentamicin reduced significantly the incidence of colonization of the tracheal secretions by Gram-negative rods (p<0.01) and decreased significantly the frequency of bacteriologically proved episodes of respiratory tract infections (p <0.01). Bacteria isolated from patients treated with gentamicin were slightly more resistant to gentamicin than the microorganisms recovered from the respiratory tract of salinetreated control patients. It is concluded that endotracheal administration of gentamicin to patients with tracheostomy may be a helpful adjunct to their management; however, special attention should be paid to the possible emergence of gentamicin-resistant microorganisms during this form of treatment.