Portal de Periódicos da CAPES

Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3

2007; Elsevier BV; Volume: 17; Issue: 12 Linguagem: Inglês

10.1016/j.bmcl.2007.03.106

1464-3405

Michael G. Johnson, An‐Rong Li, Jiwen Liu, Zice Fu, Liusheng Zhu, Shichang Miao, Xuemei Wang, Qingge Xu, Alan Huang, Andrew P. Marcus, Feng Xu, Karen Ebsworth, Emmanuel Sablan, Jay Danao, Jeff Kumer, Dan Dairaghi, Chris E. Lawrence, Timothy J. Sullivan, George Tonn, Thomas J. Schall, Tassie L. Collins, Julio C. Medina,

RNA Interference and Gene Delivery

A series of quinazolinone-derived inhibitors of the CXCR3 receptor have been synthesized and their affinity for the receptor evaluated. Compounds were evaluated in a (125)I-IP10 displacement assay and in in vitro cell migration assays to IP10, ITAC, and MIG using human peripheral blood mononuclear cells.