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Thrombosis in the newborn: Comparison between infants of diabetic and nondiabetic mothers

1965; Elsevier BV; Volume: 67; Issue: 4 Linguagem: Inglês

10.1016/s0022-3476(65)80424-3

1097-6833

Ella H. Oppenheimer, John R. Esterly,

Blood Coagulation and Thrombosis Mechanisms

Venous thrombosis was present in 45 newborn infants in a series of 4,000 cases reviewed. The incidence in infants of diabetic mothers was 15.8 per cent (13 of 82 cases), compared to an incidence of less than 1 per cent in the remaining cases. The adrenal and renal veins were most frequently involved, each comprising one third of the cases. Thrombosis was associated with hydramnios, toxemia, birth trauma, sepsis, and recent surgery. Infection and surgery were contributing factors in infants of nondiabetic mothers, whereas a history of hydramnios and toxemia occurred more frequently in infants born to diabetic women. The latter survived for shorter periods, and the thrombus in these cases showed more frequent organization and calcification, suggesting intrauterine formation. Venous thrombosis was present in 45 newborn infants in a series of 4,000 cases reviewed. The incidence in infants of diabetic mothers was 15.8 per cent (13 of 82 cases), compared to an incidence of less than 1 per cent in the remaining cases. The adrenal and renal veins were most frequently involved, each comprising one third of the cases. Thrombosis was associated with hydramnios, toxemia, birth trauma, sepsis, and recent surgery. Infection and surgery were contributing factors in infants of nondiabetic mothers, whereas a history of hydramnios and toxemia occurred more frequently in infants born to diabetic women. The latter survived for shorter periods, and the thrombus in these cases showed more frequent organization and calcification, suggesting intrauterine formation.