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Immune Responses in Humans after 60 Days of Confinement

1995; Elsevier BV; Volume: 9; Issue: 1 Linguagem: Inglês

10.1006/brbi.1995.1007

1090-2139

Didier Schmitt, Carlos A. Peres, Gerald Sonnenfeld, JEAN TKACKZUK, M. Arquier, Gérard Mauco, Elan Ohayon,

Stress Responses and Cortisol

A confinement experiment in a normobaric diving chamber was undertaken to better understand the effect of confinement and isolation on human psychology and physiology. Pre- and postconfinement blood samples were obtained from four test subjects and control donors to analyze immune responses. No modification in the levels of CD2+, CD3+, CD4+, CD8+, CD19+, and CD56+ cells was observed after confinement. Mitogen-induced T-lymphocyte proliferation and interleukin-2 receptor expression were not altered significantly. Whole blood interferon-α and -γ induction and plasma cortisol levels were also unchanged, as was natural killer cell activity. These data suggest that in humans, no specific components of the immune response are affected by a 2-month isolation and confinement of a small group.