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Profile of Kazutoshi Mori and Peter Walter, 2014 Lasker Basic Medical Research Awardees: The unfolded protein response

2014; National Academy of Sciences; Volume: 111; Issue: 50 Linguagem: Inglês

10.1073/pnas.1419343111

1091-6490

Andrew Dillin,

Protein Structure and Dynamics

Bill Clinton was inaugurated as the 42nd president of the United Sates, Whitney Houston dominated the record charts, and the Noble Peace Prize was awarded to Mandela and de Klerk. Meanwhile, two groups quietly working in Texas and California would let curiosity lead them to uncover a mechanism of life essential for the evolution of multicellularity: the unfolded protein response (UPR). The year was 1993. It was a moment during which Peter Walter and Kazutoshi Mori (Fig. 1) would first describe a system that addressed one of the fundamental mysteries of the cell: how it could ensure that the millions of proteins it created and secreted were folded and functioning properly.