Carcinoma ex pleomorphic adenoma: Diagnostic difficulty and outcome
2008; Wiley; Volume: 138; Issue: 5 Linguagem: Inglês
10.1016/j.otohns.2008.01.013
ISSN1097-6817
AutoresPeter Zbären, Sibylle Zbären, Marco Caversaccio, Edouard Stauffer,
Tópico(s)Oral and Maxillofacial Pathology
ResumoObjective To analyze a series of carcinoma ex pleomorphic adenoma (CXPA) and to assess the diagnostic difficulties. Study Design The clinical presentation of 24 CXPAs was compared with 300 pleomorphic adenomas (PAs). Furthermore, pathohistological findings and follow‐up results of CXPAs were evaluated. Results Eight of 24 (33%) CXPAs versus 41 of 300 (14%) PAs were localized in the deep lobe ( P < 0.05). Forty‐two percent of CXPAs versus 6 percent of PAs, respectively, were greater than 4 cm ( P < 0.05). The sensitivity in detecting CXPA by fine‐needle aspiration cytology (FNAC) was 47 percent. The tumor was known to be malignant preoperatively in 10 (42%) patients. Six of 24 (25%) patients with CXPA developed a tumor recurrence. The overall 5‐year survival rate of CXPA was 76 percent. Conclusion CXPAs are difficult to identify preoperatively. FNAC has a low accuracy and sensitivity. CXPAs versus PAs are significantly more frequently localized in the deep lobe and are significantly greater in size.
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