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Association of the BDNF Val66Met variation with obesity in women

2008; Elsevier BV; Volume: 95; Issue: 1-2 Linguagem: Inglês

10.1016/j.ymgme.2008.06.008

1096-7206

Sigri Beckers, Armand V. Peeters, Doreen Zegers, Ilse Mertens, Luc Van Gaal, Wim Van Hul,

Neurogenesis and neuroplasticity mechanisms

Brain-derived neurotrophic factor (BDNF) has been implied in the regulation of food intake. In the present study, we genotyped the Val66Met polymorphism in a Belgian cohort of 532 obese women and 197 healthy female controls and were, for the first time, able to show an association of the 66Met allele with obesity, at least in our female cohort.