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Cytogenetic and fluorescence in situ hybridization investigation of ring chromosomes characterizing a specific pathologic subgroup of adipose tissue tumors

1993; Elsevier BV; Volume: 68; Issue: 2 Linguagem: Inglês

10.1016/0165-4608(93)90001-3

1873-4456

Paola Dal Cin, Patrick Kools, Raf Sciot, Ivo De Wever, Boudewijn Van Damme, Wim Van de Ven, Herman Van den Berghe,

RNA modifications and cancer

Cytogenetic analysis of 184 adipose tissue tumors, 175 lipomas, and nine liposarcomas (LPS) showed the presence of a ring chromosome and/or a long marker chromosome in 10 cases with common histologic features such as atypical stromal cells with or without lipoblasts. In five of the cases, this appeared to be the sole cytogenetic abnormality. Fluorescence in situ hybridization (FISH) analysis with a microclone library specific for chromosome region 12q13-q15 showed extensive staining of the ring and long marker chromosomes, indicating that genetic sequences of this particular region of chromosome 12 are present in these marker chromosomes, most likely in an amplified form.