The ring expansion of penama to cephams: a possible biomimetic process
1988; Elsevier BV; Volume: 44; Issue: 18 Linguagem: Inglês
10.1016/s0040-4020(01)81453-8
ISSN1464-5416
AutoresJack E. Baldwin, Robert M. Adlington, Tae Won Kang, Eun Lee, Christopher J. Schofield,
Tópico(s)Marine Toxins and Detection Methods
ResumoReaction of a 2β-bromomethyl penam with triphenyltin hydride gave, via ring expansion of the derived 2β-methyl radical, the corresponding cepham system; a similar process may be in operation during the biosynthetic ring expansion of penicillin N to deacetoxycephalasporin C.1
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