Synthesis of 5-N-acetylardeemin seco-analogues
1998; Elsevier BV; Volume: 54; Issue: 5-6 Linguagem: Inglês
10.1016/s0040-4020(97)10364-7
ISSN1464-5416
AutoresJuan Domingo Sánchez, M. Teresa Ramos, Carmen Avendaño,
Tópico(s)Carbohydrate Chemistry and Synthesis
ResumoPiperazinediones derived from ehtyl N-indolylmethyl- glicinate or L-alaninate and different α-amino esters were cyclized with anthranilic acid in two steps with retention of configuration of the stereocenters to afford compounds which are analogues of 5-N-acetylardeemin, a MDR reversal agent.
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