Synthesis and biological properties of new 1β-methylcarbapenems having tetrazolothioether moiety
2000; Elsevier BV; Volume: 10; Issue: 13 Linguagem: Inglês
10.1016/s0960-894x(00)00253-5
ISSN1464-3405
AutoresKye Jung Shin, Ki Dong Koo, Kyung Ho Yoo, Dong Chan Kim, Dong Jin Kim, Sang Woo Park,
Tópico(s)Antibiotic Resistance in Bacteria
ResumoThe synthesis and biological activities of a series of new 1beta-methylcarbapenems 1a-l having tetrazolothioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1c showed the most potent antibacterial activity and advanced pharmacokinetics compared with imipenem and meropenem.
Referência(s)