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Lipid-Coating on Polyamide Microcapsules Having Long Alkyl Chains and the Characterization of the Lipid-Coated Surface

1989; Oxford University Press; Volume: 62; Issue: 11 Linguagem: Inglês

10.1246/bcsj.62.3587

1348-0634

Kenji Kono, Shunsaku Kimura, Yukio Imanishi,

Advanced Polymer Synthesis and Characterization

Abstract Polyamide microcapsules with diameters in the range of 1–5 μm were prepared by interfacial polycondensation between terephthaloyl dichloride and a mixture of l-lysine and piperazine. The carboxyl groups of l-lysine residues involved in the polyamide microcapsules were reacted with alkylamine by using water-soluble carbodiimide as a coupling reagent. The alkylated polyamide microcapsules were incubated with liposome to have the surface of the polyamide microcapsules coated with lipid bilayer membrane. The amount of lipid assemblies adsorbed on the polyamide microcapsules with octyl chains increased up to 1.5 times as much as that on the polyamide microcapsules without octyl chains. The synthetic glycopeptides were introduced to the lipid membrane adsorbed on the surface of the polyamide microcapsules. Interactions of the glycopeptides with the lipid membrane on the polyamide microcapsules and of the glycopeptides in the lipid membrane on the polyamide microcapsules with lectin were investigated.