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Antimalarial Agents from Plants II. Decursivine, A New Antimalarial Indole Alkaloid from Rhaphidophora decursiva

2002; Taylor & Francis; Volume: 40; Issue: 3 Linguagem: Inglês

10.1076/phbi.40.3.221.5832

1744-5116

Hongjie Zhang, Sheng‐Xiang Qiu, Pamela Tamez, Ghee Teng Tan, Zeynep Aydoğmuş, Nguyễn Văn Hùng, Nguyễn Mạnh Cường, Cindy K. Angerhofer, Djaja D. Soejarto, John M. Pezzuto, Harry H. S. Fong,

Chemical synthesis and alkaloids

Antimalarial bioassay-directed fractionation led to the isolation of a new active indole alkaloid, decursivine (1), from the leaves and stems of Rhaphidophora decursiva Schott (Araceae). In addition, a leaf sample yielded the structurally-related compound serotobenine (2), previously reported from a taxonomically unrelated family, which was not active against Plasmodium falciparum. The structure of 1 was elucidated by spectroscopic means, and its antimalarial activity was observed with IC 50 values of 3.93 and 4.41µg/ml against the D6 and W2 clones of Plasmodium falciparum, respectively.