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Stability of [Mg 2+ ] in Cerebrospinal Fluid during Plasma Changes and during Hypercapnia in Young and in Adult Rats

1971; Wiley; Volume: 82; Issue: 4 Linguagem: Inglês

10.1111/j.1748-1716.1971.tb04991.x

1365-201X

Ole Olsen, S C Sorensen,

Ion Transport and Channel Regulation

Abstract This investigation was undertaken to examine whether the rat, like other mammals that have been studied, maintains a stable concentration of Mg 2+ in cerebrospinal fluid (CSF) when the plasma Mg 2+ concentration is changed. CSF was sampled from the cisterna magna in adult rats made hypomagnesemic by being fed a magnesium‐free diet. The [Mg 2+ ] in CSF did not decrease significantly during hypomagnesia, in disagreement with previous findings in the rat. The disagreement could have been due to a difference in the age of the animals when they were studied, cation transport processes possibly being incompletely developed in young rats, but we found that rats 3 to 4 weeks old also maintained a stable [Mg 2+ ] in CSF during hypo‐niagnesemia. The effect of 4 hrs of hypercapnia on the [Mg 2+ ] in CSF was examined in normal hypomagnesemic adult rats. Hypercapnia did not affect the [Mg 2+ ] in CSF in either group.