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Inhibition of an in Vivo Antigen-Specific IgE Response by Antibodies to CD23

1993; American Association for the Advancement of Science; Volume: 261; Issue: 5124 Linguagem: Inglês

10.1126/science.8351517

1095-9203

Leopoldo Flores‐Romo, John Shields, Yves Humbert, Pierre Graber, Jean‐Pierre Aubry, Jean‐François Gauchat, Guidon Ayala, Bernard Allet, M.E. Flores Chávez, Hervé Bazin, Moníque Capron, Jean‐Yves Bonnefoy,

Asthma and respiratory diseases

Immunoglobulin E (IgE) mediates many allergic responses. CD23 is a 45-kilodalton type II transmembrane glycoprotein expressed in many cell types. It is a low-affinity IgE receptor and interacts specifically with CD21, thereby modulating IgE production by B lymphocytes in vitro. In an in vivo model of an allergen-specific IgE response, administration of a rabbit polyclonal antibody to recombinant human truncated CD23 resulted in up to 90 percent inhibition of ovalbumin-specific IgE synthesis. Both Fabs and intact IgG inhibited IgE production in vitro and in vivo. Thus, CD23 participates in the regulation of IgE synthesis in vivo and so could be important in allergic disease.