Metabolism of taurine in the growing chicken
1957; Elsevier BV; Volume: 70; Issue: 1 Linguagem: Inglês
10.1016/0003-9861(57)90077-2
ISSN1096-0384
Autores Tópico(s)Pharmaceutical and Antibiotic Environmental Impacts
Resumo1. When taurine-S35 was injected into young chickens fed a diet slightly deficient in the sulfur-containing amino acids, only 16% of the S35 was excreted after 1 day and a total of 39% 9 days after the injection. 2. The incorporation of S35 into tissues 1 day after injection of taurine-S 35 varied considerably. The heart, tissues of the gastrointestinal tract, and the spleen contained the highest concentration of radioactivity. 3. Only a trace of S35 could be recovered in the protein fraction of these tissues; small amounts occurred in the bile acid fraction with the major portion in the protein-free extracts. The radioactivity in these extracts was largely accounted for as taurine-S35. In the liver and kidney, however, a taurine-containing conjugate accounted for a large portion of the S35. 4. When taurine-S35 was administered orally, 80% of the S35 recovered in the excreta was accounted for as taurine, 4% as bile acids, 2% as sulfate, 7% as unidentified compounds, and 7% as a compound apparently identical to the taurine conjugate found in tissues. This compound yielded taurine-S35, ornithine, and several other ninhydrin-reactive compounds after acid hydrolysis. 5. When arginine was administered concomitantly with taurine-S35, excretion of S35 was greatly diminished.
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