Antimicrobial Activities of Hydrophobic 2-Arylbenzofurans and an Isoflavone against Vancomycin-Resistant Enterococci and Methicillin-Resistant Staphylococcus aureus
2004; Thieme Medical Publishers (Germany); Volume: 70; Issue: 7 Linguagem: Inglês
10.1055/s-2004-827196
ISSN1439-0221
AutoresToshio Fukai, Yukio Oku, Yoshio Hano, Sumio Terada,
Tópico(s)Bioactive Compounds and Antitumor Agents
ResumoEight 2-arylbenzofurans and an isoflavone isolated from medicinal plants were tested for their antimicrobial activities against vancomycin-resistant enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). Among these compounds, six hydrophobic 2-arylbenzofurans (log P = 4.4 - 8.7) exhibited considerable antibacterial activity against five VRE strains (VanA-, VanB-, and VanC-phenotypes) (MICs = 3.13 - 6.25 μg/mL). Five compounds also showed antibacterial activity against ten MRSA strains (MIC80 = 3.13 μg/mL).
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