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Oral tetracycline phosphate complex (Tetrex) in the treatment of non-specific urethritis.

1969; BMJ; Volume: 45; Issue: 1 Linguagem: Inglês

10.1136/sti.45.1.50

1472-3263

E B Wijetunga, R S Morton,

Urinary Bladder and Prostate Research

The role of the tetracyclines is well established in the treatment of non-specific urethritis (NSU).This paper reports a ttrial of orally-administered tetracycline phosphate complex (Tetrex), a com- bination of acidified sodium hexametaphosphate with acidified tetracycline hydrochloride in the ratio of 3:1.This preparation is said to be absorbed from the alimentary tract more efficiently than the hydrochloride combination and to give blood con- centrations twice as high (Shidlovsky, Prigot, Maynard, Felix, and Hjelt-Harvey, 1958).These properties, it is claimed, give the phosphate com- plex an advantage over other tetracycline analogues in that effective blood levels can be maintained with a 12-hour dosage regimen (Olon and Holvey, 1968).The promised advantages of ease of admini- stration and convenience to the patient, together with the experience of one of us (Statham and Morton, 1968) in the use of Tetrex PMT, a parent- eral preparation of rolitetracycline nitrate, led us to believe that a trial of oral tetracycline phosphate complex should be undertaken.