Herpes zoster and the immunocompromised
1987; Elsevier BV; Volume: 14; Issue: 1 Linguagem: Inglês
10.1016/s0163-4453(87)90652-9
ISSN1532-2742
Autores Tópico(s)Cytomegalovirus and herpesvirus research
ResumoVaricella zoster virus (VZV) is an exclusively human neurotropic alphaherpesvirus. Primary infection causes varicella (chickenpox), after which virus becomes latent in cranial nerve ganglia, dorsal root ganglia, and autonomic ganglia along the entire neuraxis. Years later, in association with a decline in cell-mediated immunity in elderly and immunocompromised individuals, VZV reactivates and causes a wide range of neurologic disease. This article discusses the clinical manifestations, treatment, and prevention of VZV infection and reactivation; pathogenesis of VZV infection; and current research focusing on VZV latency, reactivation, and animal models.
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