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Consecutive Gold(I)-Catalyzed Cyclization Reactions of o -(Buta-1,3-diyn-1-yl-)-Substituted N -Aryl Ureas: A One-Pot Synthesis of Pyrimido[1,6- a ]indol-1(2 H )-ones and Related Systems

2013; American Chemical Society; Volume: 15; Issue: 11 Linguagem: Inglês

10.1021/ol4007986

1523-7060

Phillip P. Sharp, Martin G. Banwell, Jens Renner, Klaas Lohmann, Anthony C. Willis,

Cyclopropane Reaction Mechanisms

Treatment of readily available o-(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas such as 1 with the Au(I)-catalyst 11 affords, via a twofold cyclization process, the isomeric pyrimido[1,6-a]indol-1(2H)-one 3 in good yield.