Sensitivity and specificity of anti‐Jo‐1 antibodies in autoimmune diseases with myositis
1996; Wiley; Volume: 39; Issue: 2 Linguagem: Inglês
10.1002/art.1780390218
ISSN1529-0131
AutoresDolores Vázquez‐Abad, Naomi F. Rothfield,
Tópico(s)Skin Diseases and Diabetes
ResumoTo determine the sensitivity and specificity of anti-Jo-1 in systemic sclerosis (SSc) patients with and without myositis.Immunoblots on HeLa nuclei were used to screen sera from 554 consecutive connective tissue disease patients. Those who had 45-55-kd bands, all patients with polymyositis/dermatomyositis (PM/DM), and a random selection of SSc, Raynaud's disease, systemic lupus erythematosus, and rheumatoid arthritis patients were also studied by anti-Jo-1 enzyme-linked immunosorbent assay and by immunoblots on rabbit pooled aminoacyl-transfer RNA synthetase.Anti-Jo-1 was present only in 8 of the 40 PM/DM patients.Anti-Jo-1 is specific for PM/DM.
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