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In vitro assessment of the adhesiveness of film-coated tablets

1986; Elsevier BV; Volume: 34; Issue: 1-2 Linguagem: Inglês

10.1016/0378-5173(86)90011-6

1873-3476

H. Al-Dujaili, Alastair J. Florence, Eugene G. Salole,

Pharmaceutical studies and practices

A method has been developed to assess the adhesivity of capsules and film-coated tablets. The adhesiveness of tablets, a property important during aqueous film-coating processes and oesophageal transit, has been studied using a strain gauge device to measure the force required to detach the dosage form from a planar moist surface. The results obtained by this method correlate well with those obtained using an ex vivo method involving strips of porcine oesophageal mucosa. Non-disintegrating tablets were coated with hydroxypropyl cellulose (HPC), hydroxypropylmethyl cellulose (HPMC) and the polymethacrylate copolymers Eudragit E100 and L100. The influence of film-coat thickness, and added poly(oxyethylene) glycol (PEG) of varying molecular weight was studied. While Eudragit polymers had little adhesive potential, HPC and HPMC film-coats became more adhesive with increase in film thickness, but the presence of PEG of molecular weight > 1000 markedly reduced adhesiveness.