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Occlusive patch method for skin sensitization in guinea pigs: The Buehler method

1994; Elsevier BV; Volume: 32; Issue: 2 Linguagem: Inglês

10.1016/0278-6915(94)90169-4

1873-6351

E.V. Buehler,

Animal testing and alternatives

Currently, the European Community is in the process of discussing the details of how to conduct various protocols for safety assessment. Additionally, there is a desire that these protocols be harmonized internationally. This presentation attempts to describe the critical and non-critical parameters of the protocol for detecting potential contact allergens in the guinea pig and also discusses some controversial issues. It is also emphasized that the identification of a test material as a potential sensitizer is only the first step in the risk-assessment exercise.