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Cellular senescence and chromatin organisation

2007; Springer Nature; Volume: 96; Issue: 5 Linguagem: Inglês

10.1038/sj.bjc.6603636

1532-1827

Masashi Narita,

Epigenetics and DNA Methylation

Despite the potential importance of senescence in tumour suppression, its effector mechanism is poorly understood. Recent studies suggest that alterations in the chromatin environment might add an additional layer of stability to the phenotype. In this review, recent discoveries on the interplay between senescence and chromatin biology are overviewed.