A facile lipase-catalyzed resolution of 2-azabicyclo[2.2.1]hept-5-en-3-ones
1994; Elsevier BV; Volume: 5; Issue: 7 Linguagem: Inglês
10.1016/0957-4166(94)80144-4
ISSN1362-511X
AutoresHiroto Nakano, Yuko Okuyama, Kazuto Iwasa, Hiroshi Hongo,
Tópico(s)Pharmacogenetics and Drug Metabolism
ResumoThe lipase-catalyzed asymmetric synthesis of optically active 2-azabicyclo[2.2.1]hept-5-en-3-ones is reported. Chiral 2-azabicyclo[2.2.1]hept-5-en-3-ones were obtained conveniently by lipase-catalyzed enantioselective transesterification of 2-hydroxymethyl-2-azabicyclo-[2.2.1]-hept-5-en-3-one.
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