Costs and Benefits of High Mutation Rates: Adaptive Evolution of Bacteria in the Mouse Gut
2001; American Association for the Advancement of Science; Volume: 291; Issue: 5513 Linguagem: Inglês
10.1126/science.1056421
ISSN1095-9203
AutoresAntoine Giraud, Ivan Matić, Olivier Tenaillon, Antonio Clara, Miroslav Radman, Michel Fons, François Taddéi,
Tópico(s)Bacterial Genetics and Biotechnology
ResumoWe have shown that bacterial mutation rates change during the experimental colonization of the mouse gut. A high mutation rate was initially beneficial because it allowed faster adaptation, but this benefit disappeared once adaptation was achieved. Mutator bacteria accumulated mutations that, although neutral in the mouse gut, are often deleterious in secondary environments. Consistently, the competitiveness of mutator bacteria is reduced during transmission to and re-colonization of similar hosts. The short-term advantages and long-term disadvantages of mutator bacteria could account for their frequency in nature.
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