Addenbrooke's Cognitive Examination‐Revised for mild cognitive impairment in Parkinson's disease
2012; Wiley; Volume: 27; Issue: 9 Linguagem: Inglês
10.1002/mds.25084
ISSN1531-8257
AutoresPeter McColgan, Jonathan Evans, David P. Breen, Sarah Mason, Roger A. Barker, Caroline H. Williams‐Gray,
Tópico(s)Ginkgo biloba and Cashew Applications
ResumoAbstract Introduction: Cognitive impairment is common in Parkinson's disease (PD), even in the early stages, and appropriate screening tools are needed. Methods: We investigated the utility of the Addenbrooke's Cognitive Examination‐Revised for detecting mild cognitive impairment (MCI) in PD in an incident population‐representative cohort (n = 132) and investigated the relationship between performance on this instrument and behavior and quality of life (n = 219). Results: Twenty‐two percent met criteria for MCI. Receiver operating curve analysis revealed an area under the curve of 0.81. A cutoff <89 gave a sensitivity of 69% and specificity of 84%. Scores on this instrument were highly correlated with the Parkinson's Disease Cognitive Rating Scale, and there were significant correlations with the Cambridge Behavioral Inventory‐Revised and Parkinson's Disease Questionnaire 39. Conclusion: This instrument is a useful screening tool for PD‐MCI, and poor performance is significantly related to impaired behavior and quality of life. © 2012 Movement Disorder Society
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