A comparison of propafenone and amiodarone in reversion of recent-onset atrial fibrillation to sinus rhythm
1994; Elsevier BV; Volume: 55; Issue: 11 Linguagem: Inglês
10.1016/s0011-393x(05)80319-4
ISSN1879-0313
AutoresM. Negrini, G Gibelli, Carlo De Ponti,
Tópico(s)Cardiac Arrhythmias and Treatments
ResumoAbstract In a single-blind, randomized study, the effectiveness of propafenone and amiodarone for reversion of recent-onset (≤1 week) atrial fibrillation was compared in 61 consecutive patients (New York Heart Association functional class I and II). Thirty-one patients were treated with propafenone (2 mg/kg intravenously over 10 minutes followed by a continuous infusion of 0.007 mg/kg per minute) and 30 patients with amiodarone (5 mg/kg intravenously over 10 minutes followed by an infusion of 15 mg/kg per day). Drug efficacy was measured by rate of reversion to sinus rhythm within 1 hour after the start of drug infusion. At 1 hour, 13 patients reverted with propafenone treatment and 3 with amiodarone treatment (42% vs 10%, P P = NS). The median time to conversion was shorter for propafenone than for amiodarone (90 minutes vs 450 minutes, P
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