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Sinoaortic baroreceptor reflex arc modulation of nociception in spontaneously hypertensive and normotensive rats

1982; Springer Nature; Volume: 10; Issue: 2 Linguagem: Inglês

10.3758/bf03332947

0090-5046

Alan Randich,

Neuroscience of respiration and sleep

Spontaneously hypertensive rats of the Okamoto-Aoki strain (SHR) and normotensive rats of the Wistar-Kyoto strain (WKY) were assessed in hot-plate and flinch-jump analgesimetric assays. SHRs manifested longer latencies than WKYs to both paw-lick and jump in response to painful thermal stimulation in the hot-plate assay, but SHRs had lower flinch and jump thresholds than WKYs to electric shock stimulation in the flinch-jump assay. Bilateral sinoaortic deafferentation did not alter response latencies of either SHRs or WKYs in the hotplate assay, but significantly lowered flinch and jump thresholds of both SHRs and WKYs in the flinch-jump assay. These findings are discussed in terms of baroreceptor reflex arc modulation of endogenous pain-regulatory systems and motor control.