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A quantitative analysis of tryptophan metabolism during development of the blowfly Protophormia terrae-novae

1974; Elsevier BV; Volume: 4; Issue: 3 Linguagem: Inglês

10.1016/0020-1790(74)90055-9

1879-2928

Bernt Linzen, Walter SCHARTAU,

Stress Responses and Cortisol

During metamorphosis of Protophormia terrae-novae, tryptophan is degraded quantitatively to kynurenine, 3-hydroxykynurenine, and xanthommatin; kynurenic and xanthurenic acids are detected in trace amounts, while anthranilic and 3-hydroxyanthranilic acids are apparently not formed. Tryptophan is taken up rapidly by growing tissues and by the excretory system. The enzymes of tryptophan catabolism were found to follow individual activity patterns during development: tryptophan oxygenase displays a U-curve, kynurenine formamidase decreases steadily from the larval to adult stages, while kynurenine hydroxylase is maximal prior to pupation.