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Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes

2007; Elsevier BV; Volume: 366; Issue: 1 Linguagem: Inglês

10.1016/j.bbrc.2007.11.119

1090-2104

Kayo Kuroyanagi, Min‐Sook Kang, Tsuyoshi Goto, Shizuka Hirai, Kana Ohyama, Tatsuya Kusudo, Rina Yu, Masamichi Yano, Takao Sasaki, Nobuyuki Takahashi, Teruo Kawada,

Adipose Tissue and Metabolism

Citrus fruit compounds have many health-enhancing effects. In this study, using a luciferase ligand assay system, we showed that citrus auraptene activates peroxisome proliferator-activated receptor (PPAR)-α and PPARγ. Auraptene induced up-regulation of adiponectin expression and increased the ratio of the amount of high-molecular-weight multimers of adiponectin to the total adiponectin. In contrast, auraptene suppressed monocyte chemoattractant protein (MCP)-1 expression in 3T3-L1 adipocytes. Experiments using PPARγ antagonist demonstrated that these effects on regulation of adiponectin and MCP-1 expression were caused by PPARγ activations. The results indicate that auraptene activates PPARγ in adipocytes to control adipocytekines such as adiponectin and MCP-1 and suggest that the consumption of citrus fruits, which contain auraptene can lead to a partial prevention of lipid and glucose metabolism abnormalities.