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BIBTEX RIS

Association between MBL2 gene functional polymorphisms and high-risk human papillomavirus infection in Brazilian women

2008; Elsevier BV; Volume: 69; Issue: 4-5 Linguagem: Inglês

10.1016/j.humimm.2008.03.002

1879-1166

Vilma Guimarães, Rafael Lima Guimarães, Lucas André Cavalcanti Brandão, Maria Fernanda Piffer Tomasi Baldez da Silva, Michele Milanese, Ludovica Segat, Carlos Henrique Madeiros Castelletti, Danielly Bruneska, Josè Luiz de Lima Filho, Antônio Carlos de Freitas, Luiz Cláudio Arraes, Cíntia Renata Costa Rocha, Sérgio Crovella,

Complement system in diseases

We studied the association between high-risk human papillomavirus (HPV) infection and MBL2 functional polymorphisms in a group of 180 high-risk HPV-infected women and 180 healthy control subjects. The most frequent high-risk HPV genotypes were 16 (47.2%), 31 (11.7%), 33 (5%), and 18 (2.2%), respectively. Of the 180 HPV-infected women, 99 presented with uterine cervical cancer and 81 did not. No differences in MBL2 genotype or in allelic or haplotype frequencies were found between HPV patients who developed cervical uterine cancer and those who did not. When considering combined genotypes grouped according to MBL production (designated as high, low, and deficient producers), we detected a significant difference between healthy controls and high-risk HPV-positive patients, the latter group showing increased frequencies of deficient-producer genotypes (14.4% vs 9.4% in the healthy control group, corrected p = 0.04). In conclusion, a correlation between MBL2 polymorphisms and high-risk HPV infection was found in this study.