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Sirtuin-1 regulation of mammalian metabolism

2010; Elsevier BV; Volume: 17; Issue: 1 Linguagem: Inglês

10.1016/j.molmed.2010.09.005

1471-499X

Matthew P. Gillum, Derek M. Erion, Gerald I. Shulman,

Autophagy in Disease and Therapy

Sirtuin-1 (SirT1) is a nutrient-sensing deacetylase whose levels and activity increase with caloric restriction to preserve euglycemia and promote efficient energy utilization. Focusing on data obtained in vivo , we review how SirT1 orchestrates the adaptive response to fasting by stimulating hepatic gluconeogenesis and fatty acid oxidation, increasing circulating adiponectin levels and limiting immune activation. Finally, we consider its viability as a therapeutic target for the treatment of type 2 diabetes.