The action of caerulein on gastric secretion of the chicken
1970; Elsevier BV; Volume: 11; Issue: 2 Linguagem: Inglês
10.1016/0014-2999(70)90050-6
ISSN1879-0712
Autores Tópico(s)Neuropeptides and Animal Physiology
ResumoCaerulein stimulated gastric secretion of the chicken, particularly after intravenous infusion. The threshold doses given by subcutaneous and intravenous injection were 10 ng/kg and 50 ng/kg respectively. Caerulein increased output of the fluid and solid components of gastric juice and generally raised the concentration of pepsin. Slight tachyphylaxis particularly on the fluid and acid components was observed. Caerulein stimulation of gastric secretion was completely inhibited by atropine but unaffected by drugs altering histamine stores. Caerulein was four time as effective on fluid and acid secretion than human gastrin I, and fifteen times as effective on pepsin secretion. Porcine secretin did not affect the chicken's gastric secretion.
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