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A NOVEL INERT COLLAGEN MATRIX FOR HYPOSPADIAS REPAIR

1999; Lippincott Williams & Wilkins; Volume: 162; Issue: 3 Part 2 Linguagem: Inglês

10.1016/s0022-5347(01)68105-9

1527-3792

Anthony Atala, Luis Guzman, Alan B. Retik,

Electrospun Nanofibers in Biomedical Applications

No AccessJournal of UrologyPapers Presented at Annual Meeting of the Section on Urology, American Academy of Pediatrics; San Francisco, California; October 17-19, 1998: Hypospadias/Phimosis/Scrotum1 Sep 1999A NOVEL INERT COLLAGEN MATRIX FOR HYPOSPADIAS REPAIR ANTHONY ATALA, LUIS GUZMAN, and ALAN B. RETIK ANTHONY ATALAANTHONY ATALA , LUIS GUZMANLUIS GUZMAN , and ALAN B. RETIKALAN B. RETIK View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)68105-9AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: In select patients with hypospadias in whom genital skin is insufficient alternative tissues are needed for urethral reconstruction. Although skin and mucosal grafts may be used, they may increase hospitalization and morbidity. We explored the feasibility of using a bladder submucosal, collagen based inert matrix as a free graft substitute for urethral repair. Materials and Methods: Four patients with a history of hypospadias underwent repeat hypospadias repair using a collagen based inert matrix for urethral reconstruction. The inert collagen matrix was trimmed to size as needed for each patient. The neourethra was created by anastomosing the matrix in an onlay fashion to the urethral plate with continuous 6-zero polyglactin sutures. The created neourethra size ranged from 5 to 15 cm. Results: After a 22-month followup 3 of the 4 patients had a successful outcome in regard to cosmesis and function. One patient in whom a 15 cm. neourethra was created had a subglanular fistula. Conclusions: The use of a collagen inert matrix appears to be beneficial in patients who have undergone previous hypospadias repair and who may lack sufficient genital skin for reconstruction. References 1 : New method of operation for male hypospadias: free transplant of ureter to form urethra. Arch. Klin. Chir.1909; 90: 748. 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Google Scholar From the Department of Urology, Children's Hospital and Harvard Medical School, Boston, Massachusetts(Atala) Requests for reprints: 300 Longwood Ave., Boston, Massachusetts 02115.© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byEl Kassaby A, AbouShwareb T and Atala A (2018) Randomized Comparative Study Between Buccal Mucosal and Acellular Bladder Matrix Grafts in Complex Anterior Urethral StricturesJournal of Urology, VOL. 179, NO. 4, (1432-1436), Online publication date: 1-Apr-2008.le ROUX P (2018) ENDOSCOPIC URETHROPLASTY WITH UNSEEDED SMALL INTESTINAL SUBMUCOSA COLLAGEN MATRIX GRAFTS: A PILOT STUDYJournal of Urology, VOL. 173, NO. 1, (140-143), Online publication date: 1-Jan-2005.SHOKEIR A, OSMAN Y, GABR M, MOHSEN T, DAWABA M and EL-BAZ M (2018) Acellular Matrix Tube for Canine Urethral Replacement:: is It Fact or Fiction?Journal of Urology, VOL. 171, NO. 1, (453-456), Online publication date: 1-Jan-2004.EL-KASSABY A, RETIK A, YOO J and ATALA A (2018) Urethral Stricture Repair With an Off-the-shelf Collagen MatrixJournal of Urology, VOL. 169, NO. 1, (170-173), Online publication date: 1-Jan-2003.De Filippo R, Yoo J and Atala A (2018) Urethral Replacement Using Cell Seeded Tubularized Collagen MatricesJournal of Urology, VOL. 168, NO. 4 Part 2, (1789-1793), Online publication date: 1-Oct-2002.Pariente J, Kim B and Atala A (2018) In Vitro Biocompatibility Evaluation Of Naturally Derived And Synthetic Biomaterials Using Normal Human Bladder Smooth Muscle CellsJournal of Urology, VOL. 167, NO. 4, (1867-1871), Online publication date: 1-Apr-2002. Volume 162Issue 3 Part 2September 1999Page: 1148-1150 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.MetricsAuthor Information ANTHONY ATALA More articles by this author LUIS GUZMAN More articles by this author ALAN B. RETIK More articles by this author Expand All Advertisement PDF downloadLoading ...