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BIBTEX RIS

Biocompatible, surface functionalized mesoporous titania nanoparticles for intracellular imaging and anticancer drug delivery

2011; Royal Society of Chemistry; Volume: 47; Issue: 18 Linguagem: Inglês

10.1039/c1cc10659g

ISSN

1364-548X

Autores

Kevin C.‐W. Wu, Yusuke Yamauchi, Chen-Yu Hong, Ya-Huei Yang, Yung-He Liang, Takashi Funatsu, Makoto Tsunoda,

Tópico(s)

Nanoparticle-Based Drug Delivery

Resumo

Mesoporous titania nanoparticles (MTNs) with excellent biocompatibility (LC(50)≈ 400 μg mL(-1)) and a large surface area (ca. 237.3 m(2) g(-1)) were synthesized and further functionalized with a phosphate-containing fluorescent molecule (i.e. flavin mononucleotide; FMN) and loaded with an anticancer drug (i.e. Doxorubicin) for successful intracellular bioimaging and drug delivery, respectively, in human breast cancer cells BT-20.

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